PEPTIDES REVIEW: SERMORELIN

Original question from Will on Quora:

I’m 55 years old, lift 4 days a week and eat pretty well. My test levels are a little low but I don’t want to start TRT and I’m looking for that little extra. What do you think about Sermorelin treatment to naturally increase HGH and possibly help test levels?

Wassup, Will, MY BRUDDAH!!

Alright, alright, bruh, so you wanna have that EXTRA edge, ugh?

In the last couple of years, it was revealed by no other than Stanford's School of Medicine's professor of Ophthalmology and Neurobiology/Podcaster Extraordinaire Dr. Andrew Huberman, that most of those Hollywood transformations that every single online Natty Or Not articles attributed to straight-up STEROID ABUSE, were actually the product of a hefty amount of PEPTIDES.

I'm still not 100% sold on that, but it makes a lot of sense— if you're a fitness geek like me, you're well aware that your average fitness influencer who abuses gear to get clicks on Instagram is 2x bigger and 5% leaner than your average actor playing a superhero in a Marvel Blockbuster— so it's not wild to assume that they're NOT throwing the kitchen sink AKA using every steroid from A-Z as some people suggest, but actually using compounds that are deemed to be safer, and potentially, pretty effective, like PEPTIDES.

Peptides are deemed to be safer, because they work by IGNITING the cascade of effects that end up releasing a specific hormone, for instance, Sermorelin is analogous to GHRH Growth Hormone Releasing Hormone, so when injected it signals the pituitary to produce growth-hormone through its natural pathway.

Let's say GH production has 5 steps, which is NOT CORRECT but serves as an example— if you just jab GH inside you, your body will identify that it already has LOTS of GH floating around the bloodstream— the final product of those 5 steps— slowly but surely generating negative feedback, that slowly downregulate those 5 steps, to a point that it eventually can shut down all GH natural production.

Sermorelin on the other hand, and several other peptides for that matter, will not interfere in those 5 steps, it'll just signal the process to start, increasing the rate at which the process itself occurs, resulting in increased growth hormone production.

In the case of Sermorelin, some of these steps prior to the GH release itself, relate to regulating your CORTISOL LEVELS indirectly, and more directly agonizing GHRELIN— the hunger hormone.

This means that Sermorelin will potentially get your autonomic nervous system ALL OVER THE PLACE, and SURE ENOUGH, get your HUNGRY AS SHIT, which can be a big problem if, like me, you tend to get a bit HANGRY HAHAHHAA

It's important to note, that even though you'll have a higher chance of having higher GH levels floating around, that can result in higher IGF-1 levels and consequently higher Testosterone levels, especially in hypogonadal males— as evidenced in double-blinded, randomized controlled trials that I'm too lazy to go find right now, but you can use the keywords "human-growth hormone secretagogues", "hypogonadism", and "sermorelin", and I'm sure you'll find them— you're STILL BOUND BY YOUR GOOD BEHAVIORAL PRACTICES.

Human Growth-Hormone in particular has a strong affinity with your circadian rhythms and REQUIRES optimal sleep to reach levels that can substantially impact your metabolism and overall performance.

The vast majority of our natural production of HGH happens in our FIRST cycle of sleep, and only if that first cycle is aligned with your circadian rhythms, meaning, it happens in the first 60-120min of sleep, and only if those 60-120min of sleep are aligned with your internal clock and happen AT THE SAME TIME OF THE DAY.

If you go to sleep at 10 pm every day, only on the days you go to sleep at 10 pm you get the big pulse of HGH— if you sleep at 1 am, you just miss it, and no amount of Sermorelin will save you.

And worse than that, if your sleep is in utter disarray— you go to sleep at a different time every day, wake up at a different time every day— then your endocrine system is already working like a Paraguayan Bootleg Action Figure Factory, things are just ALL OVER THE PLACE HAHAHAA, and that might explain your low T in the first place.

So bottom line, dude, Sermorelin is interesting— check with a decent healthcare professional if it's a sensible intervention for you, and please, do not go buy it from some shady company online, try to put your hands on pharma grade stuff, 'cause it's the WILD WILD WEST out there, these cheap compounds you find online are all made by bathtub chemists, and you can't have a single clue of what kinds of standards these fuckers use, or even if you're getting what you ordered.

Just a couple of months ago, I received an email from a dude saying he was taking Test Enanthate 500mg/week, but his test levels didn't go up, and worse, his dick went limp, and he suddenly had tits— long story short, his dealer screwed up and put Deca in the Test vials, and if you have any clue of how insanely disrupting using that amount of Deca without a test base is, you're probably cringing right now, just like I am HAHAHA— dealing with bootleg stuff can go from just DICEY to borderline DANGEROUS.

Stay safe, dude, and thanks for sending the question, I hope I was able to shed some light upon this darkness, my G!

STAY ON THE IRON PATH!

Big KISS

THE POTATO MAN